By Anthony Koleske

Abl kinfolk Kinases in improvement and illness offers an summary of the capabilities of Abl family members kinases in improvement and ailment. This new name discusses the biochemical, genetic, and mobile organic facts that elucidate the mobile roles for those kinases in those processes.

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Activation of Abl kinase by genotoxic agents has been observed in fibroblasts, fibrosarcoma cells, thymocytes, lymphoblasts, and cell lines derived from colon, breast and liver cancers. ^'^^ A 3-fold increase in Abl kinase measured by such an assay could be due a general 3-fold increase in the catalytic activity of every Abl molecule or a 100-fold increase in 3 % of the Abl. , lack of increase in Abl kinase activity, difficult to interpret. It is formally possible 28 Abl Family Kinases in Development and Disease that genotoxic agents may activate a small fraction of the cytoplasmic pool of Abl to a level that is not detectable by the immune complex kinase assay.

T h e Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin- b i n d i n g d o m a i n s to b u n d l e F-actin. Proc N a t l Acad Sci USA 2 0 0 1 ; 98(26):14865-14870. 45. Van Etten RA. Cycling, stressed-out and nervous: cellular functions of c-Abl. Trends Cell Biol 1999; 9(5):179-186. 46. Pendergast A M . T h e Abl family kinases: mechanisms of regulation and signaling. Adv Cancer Res 2002; 85:51-100. 47. T r u o n g T , Sun G, Doorly M et al. M o d u l a t i o n of D N A damage-induced apoptosis by cell a d h e s i o n is i n d e p e n d e n t l y mediated by p 5 3 and c-Abl.

P62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 1997; 88(2): 197-204. 7 1 . Yamanashi Y, Baltimore D . Identification of the Abl- and rasGAP-associated 62 IcDa protein as a docking protein, Dok. Cell 1997; 88(2):205-211. 72. Campellone KG, Rankin S, Pawson T et al. Clustering of N e k by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J Cell Biol 2004; 164(3):407-416. 73. Rivera C M , Briceno CA, Takeshima F et al.

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