By Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings

This quantity serves as a growth record on state of the art examine within the box of Alzheimer's illness and different kinds of dementia, yet with an emphasis on themes which are appropriate to scientific perform. during this most up-to-date installment, Serge Gauthier, Philip Scheltens and Jeffrey Cummings conceal many of the rising remedies for Alzheimer's disorder, together with statins, GAG minetics, and immunotherapy, in addition to using hormonal treatment and odd anti-psychotic brokers within the remedy of alternative comparable dementias. Chapters also will summarize the present realizing of the pathophysiology of gentle cognitive impairment in addition to study into tau pathologies.

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Older studies either ignore this domain entirely, or use measures that have little sensitivity to ECF. Some more recent studies include executive measures. e. verbal fluency, digit-symbol substitution, or Weschler Adult Intelligence Scale (Revised) (WAIS-R) similarities – and the Direct Assessment of Functional Status (DAFS) in AD cases. 21 reported that ECF measures add variance to functional outcomes above that attributed to ‘general’ cognitive measures, but the additional variance explained was relatively small.

Neurology 2002;58:192–197. 53. Galasko D, Hansen LA, Katzmann R, et al. Clinical-neuropathological correlations in Alzheimer’s disease and 02-Chapter 2 5 8/31/05 11:09 AM Page 32 32 ALZHEIMER’S DISEASE AND RELATED DISORDERS ANNUAL 54. 55. 56. 57. 58. 59. 60. 61. 62. related dementias. Arch Neurol 1994;51:888–895. Varma AR, Snowden JS, Lloyd JJ, et al. Evaluation of the NINCDS–ADRDA criteria in the differentiation of Alzheimer’s disease and frontotemporal dementia. J Neurol Neurosurg Psychiatry 1999; 66:184–188.

Neurocase 2005;11:32–39. de Leon MJ, Segal S, Tarshish CY, et al. Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment. Neurosci Lett 2002;333: 183–186. Buerger K, Teipel SJ, Zinkowski R, et al. CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects. Neurology 2002;59:627–629. Herukka SK, Hallikainen M, Soininen H, Pirttila T. CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment. Neurology 2005;64: 1294–1297.

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